A sensor network monitoring scheme based on short distance wireless communication technology is proposed in this paper. The MSP430 series microprocessor is used to conduct the signal conditioning and numerical processing in the design. The terminal node of patients' signs of life monitoring sensor is formed by integrating the power module, input module, wireless transmission module and LCD display module. The hardware and software of the system are designed based on the principle of blood purification. The real time network data transmission between the nodes of sensors and central node of blood purification equipment is systematically analyzed. Series problems such as the process control of blood purification in running status, real time signs monitoring of patients and real time parameters adjustment have been solved. And finally the individualized treatment and safe monitoring are achieved through the experimental simulation test.