Based on the structure and network model of the optical fiber sensor with piezoelectric ZnO coating, a target function model of power coupling efficiency has been established in this paper. A hybrid particle swarm optimization algorithm was used to optimize the power coupling efficiency parameters.The simulation results demonstrated that the algorithm has better efficiency for the power coupling efficiency network in complicated constraints.A series of device parameters data have been obtained from the simulation results.Through analyzing the optimized data,the theoretical references for the fabrication of the fiber sensor with piezoelectric ZnO coating can be provided.